Simultaneous determination of felbamate and three metabolites in human plasma by high-performance liquid chromatography
| Autor: | J. K. Wichmann, L.A. Romanyshyn, R D Sofia, Kucharczyk N |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pharmacology
Chromatography Autoanalysis Metabolite Extraction (chemistry) Phenylcarbamates High-performance liquid chromatography Biological fluid Felbamate chemistry.chemical_compound chemistry Human plasma Propylene Glycols medicine Humans Pharmacology (medical) Anticonvulsants Spectrophotometry Ultraviolet Quantitation Range Quantitative analysis (chemistry) Biotransformation Chromatography High Pressure Liquid medicine.drug |
| Zdroj: | Therapeutic drug monitoring. 16(1) |
| ISSN: | 0163-4356 |
| Popis: | An isocratic liquid-chromatographic method employing one extraction step and a 4.6 mm x 150 mm Spherisorb ODS2, 3 microns high-performance liquid chromatography (HPLC) column using ultraviolet (UV)-absorbance detection at 210 nm has been developed for quantitation of felbamate (FBM) and three felbamate metabolites in 0.100-ml aliquots of human plasma. The linear quantitation range for FBM and the two hydroxy metabolites is 0.781-200 micrograms/ml, and that for the monocarbamate metabolite is 0.391-200 micrograms/ml. |
| Databáze: | OpenAIRE |
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