Stereodivergent entry to β-branched β-trifluoromethyl α-amino acid derivatives by sequential catalytic asymmetric reactions†
| Autor: | Riccardo Riccioli, Vasco Corti, Ada Martinelli, Mariafrancesca Fochi, Luca Bernardi, Sofia Sandri |
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| Přispěvatelé: | Corti V., Riccioli R., Martinelli A., Sandri S., Fochi M., Bernardi L. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Trifluoromethyl Stereodivergency 010405 organic chemistry Stereochemistry Chemistry General Chemistry 010402 general chemistry Ring (chemistry) 01 natural sciences 0104 chemical sciences Catalysis Amino acid Transfer Hydrogenation chemistry.chemical_compound Organocatalysi Asymmetric Synthesi Chirality (chemistry) |
| Zdroj: | Chemical Science |
| ISSN: | 2041-6539 2041-6520 |
| Popis: | Currently, conventional reductive catalytic methodologies do not guarantee general access to enantioenriched β-branched β-trifluoromethyl α-amino acid derivatives. Herein, a one-pot approach to these important α-amino acids, grounded on the reduction – ring opening of Erlenmeyer–Plöchl azlactones, is presented. The configurations of the two chirality centers of the products are established during each of the two catalytic steps, enabling a stereodivergent process. A one-pot approach to β-branched β-trifluoromethyl α-amino acids, grounded on the reduction – ring opening of Erlenmeyer–Plöchl azlactones, and complementary to conventional catalytic asymmetric hydrogenation, is presented. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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