Clinical characteristics and incidence of toxoplasmosis after autologous hematopoietic stem cell transplantation: A retrospective study and literature review

Autor:	Hikaru Kobayashi, Hiroko Kazumoto, Masahiko Sumi, Hiroko Kaiume, Keijiro Sato, Toshimitsu Ueki, Yuki Hiroshima, Kazumi Norose, Masahide Watanabe, Nozomu Uematsu, Mari Kitahara, Tsutomu Shishido, Kenji Hikosaka
Rok vydání:	2021
Předmět:	Pediatrics medicine.medical_specialty medicine.medical_treatment chemical and pharmacologic phenomena Hematopoietic stem cell transplantation Transplantation Autologous Serology immune system diseases Retrospective survey hemic and lymphatic diseases medicine Humans Retrospective Studies Transplantation business.industry Incidence (epidemiology) Mortality rate Incidence Hematopoietic Stem Cell Transplantation Retrospective cohort study medicine.disease Toxoplasmosis surgical procedures operative Infectious Diseases Complication business therapeutics Toxoplasma
Zdroj:	Transplant infectious disease : an official journal of the Transplantation SocietyREFERENCES. 23(6)
ISSN:	1399-3062
Popis:	Background Toxoplasmosis is a rare but life-threatening infection occurring in immunocompromised hosts, including allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. However, thus far, the clinical features and incidence of toxoplasmosis in autologous HSCT (auto-HSCT) recipients remain unknown. This retrospective survey aimed to analyze 152 patients who received auto-HSCT between 1998 and 2017. Methods Serological tests for Toxoplasma gondii-specific IgG were performed on 109 (71.7%) recipients, and 12 pre-HSCT recipients (11%) were Toxoplasma seropositive. Among the 12 recipients, 3 who did not receive trimethoprim-sulfamethoxazole (TMP/SMX) prophylaxis developed cerebral, pulmonary, or disseminated toxoplasmosis due to reactivation after auto-HSCT and died despite treatment. Results The incidences of toxoplasmosis were 2% and 25% among 152 auto-HSCT recipients (five recipients received auto-HSCT two times) and 12 pre-HSCT Toxoplasma seropositive recipients, respectively. Further, we conducted a literature review and identified 21 cases of toxoplasmosis following auto-HSCT. In these previous cases, the mortality rate was high, especially for pulmonary and disseminated toxoplasmosis. Our findings suggest that, similar to toxoplasmosis after allo-HSCT, toxoplasmosis after auto-HSCT is a fatal complication. Conclusions Serial screening of T. gondii-specific IgG before HSCT could contribute to the detection of Toxoplasma reactivation and allow for prompt diagnosis and treatment. The present study is the first to reveal the incidence of toxoplasmosis after auto-HSCT among seropositive patients in Japan. This article is protected by copyright. All rights reserved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982763da8867ec6a4422f52c070c080e https://pubmed.ncbi.nlm.nih.gov/34542220 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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