Antifungal drugs during pregnancy: an updated review
| Autor: | Jack D. Sobel, Caroline Charlier, Benoit Pilmis, Olivier Lortholary, Marc Lecuit, Vincent Jullien |
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| Přispěvatelé: | Centre d'infectiologie Necker-Pasteur [CHU Necker], Institut Pasteur [Paris] (IP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Wayne State University [Detroit], Université Paris Descartes - Paris 5 (UPD5), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service des Maladies infectieuses et tropicales [CHU Necker], This study was supported by internal funding, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut Pasteur [Paris], Institut Pasteur [Paris]-CHU Necker - Enfants Malades [AP-HP], Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP]-Institut des Maladies Génétiques Imagine [Paris] |
| Rok vydání: | 2014 |
| Předmět: |
Antifungal Agents
MESH: Administration Intravenous [SDV]Life Sciences [q-bio] Antifungal drugs Administration Topical Pharmacology MESH: Pregnancy 0302 clinical medicine [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Pregnancy Medicine Pharmacology (medical) 030212 general & internal medicine Pregnancy Complications Infectious Fluconazole [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology 030219 obstetrics & reproductive medicine MESH: Administration Topical 3. Good health fetus MESH: Teratogens [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Infectious Diseases Teratogens fungal infections MESH: Fluconazole Liposomal amphotericin Administration Intravenous Female Itraconazole Microbiology (medical) placenta 03 medical and health sciences Animal data MESH: Anti-Infective Agents Local MESH: Mycoses Amphotericin B MESH: Amphotericin B Humans MESH: Pregnancy Complications Infectious MESH: Humans business.industry MESH: Antifungal Agents bacterial infections and mycoses antifungal therapy Mycoses Anti-Infective Agents Local business MESH: Female MESH: Itraconazole [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology Classics |
| Zdroj: | Journal of Antimicrobial Chemotherapy Journal of Antimicrobial Chemotherapy, 2014, 70 (1), pp.14-22. ⟨10.1093/jac/dku355⟩ Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2014, 70 (1), pp.14-22. ⟨10.1093/jac/dku355⟩ |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/dku355⟩ |
| Popis: | International audience; Antifungal prescription remains a challenge in pregnant women because of uncertainties regarding fetal toxicity and altered maternal pharmacokinetic parameters that may affect efficacy or increase maternal and fetal toxicity. We present updated data reviewing the available knowledge and current recommendations regarding antifungal prescription in pregnancy. Amphotericin B remains the first-choice parenteral drug in spite of its well-established toxicity. Topical drugs are used throughout pregnancy because of limited absorption. Recent data have clarified the teratogenic effect of high-dose fluconazole during the first trimester and provided reassuring cumulative data regarding its use at a single low dose in this key period. Recent data have also provided additional safety data on itraconazole and lipidic derivatives of amphotericin B. Regarding newer antifungal drugs, including posaconazole and echinocandins, clinical data are critically needed before considering prescription in pregnancy. |
| Databáze: | OpenAIRE |
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