Genomic-scale prioritization of drug targets: the TDR Targets database

Autor:	Christiane Hertz-Fowler, John P. Overington, Robert K. Campbell, Aaron Riechers, Frederick S. Buckner, Arnab Pain, Fernán Agüero, Solomon Nwaka, A. W. Edith Chan, David S. Roos, Andrej Sali, Ian M. Carruthers, Stuart A. Ralph, Dhanasekaran Shanmugam, Maria A. Doyle, Gregory J. Crowther, Takashi Suzuki, Ursula Pieper, Wesley C. Van Voorhis, Bissan Al-Lazikani, Gregg McAllister, Andrew L. Hopkins, Feng Chen, Santiago J. Carmona, Matthew Berriman, Christophe L. M. J. Verlinde, Martin Aslett, G. V. Paolini
Rok vydání:	2008
Předmět:	Pharmacology Prioritization Drug Database Drug discovery Scale (chemistry) Genomic data media_common.quotation_subject Druggability Tropical disease General Medicine Biology medicine.disease computer.software_genre Article Identification (information) Drug Discovery medicine computer media_common
Zdroj:	Nature Reviews Drug Discovery. 7:900-907
ISSN:	1474-1784 1474-1776
Popis:	The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDRtargets.org database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritisation of candidate drug targets for pathogens.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9823093a7520255d7a6fb7965eeb576c https://doi.org/10.1038/nrd2684 Zobrazit plný text záznamu Plný text ve formátu PDF