Abnormal expression of MHC class II and ICAM-1 by melanocytes in vitiligo
| Autor: | Gudgeon Je, Gracie Ja, Foulis Ak, al Badri Am, Todd Pm, Gariouch Jj, D. G. Stewart, Goudie Rb |
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| Rok vydání: | 1993 |
| Předmět: |
Helper T lymphocyte
Antigen presentation Vitiligo medicine.disease_cause Autoimmune Diseases Pathology and Forensic Medicine Autoimmunity Immune system medicine Humans Psoriasis skin and connective tissue diseases Pigmentation disorder MHC class II integumentary system biology Histocompatibility Antigens Class II Intercellular Adhesion Molecule-1 medicine.disease Intercellular adhesion molecule Immunohistochemistry Immunology biology.protein Melanocytes Cell Adhesion Molecules |
| Zdroj: | The Journal of Pathology. 169:203-206 |
| ISSN: | 1096-9896 0022-3417 |
| DOI: | 10.1002/path.1711690205 |
| Popis: | The relationship between damage to cutaneous melanocytes and antimelanocyte autoimmunity in vitiligo is unclear. We have demonstrated abnormal expression of MHC class II molecules by perilesional melanocytes in 13/21 patients with vitiligo and a six-fold increase in the number expressing the intercellular adhesion molecule ICAM-1. These molecules have important roles in normal antigen presentation and activation of helper T lymphocytes, and their expression by melanocytes may contribute to the abnormal immune response in vitiligo. MHC class II is not expressed by melanocytes in psoriasis and is unlikely to be induced in vitiligo by cytokines released from activated non-melanocyte-specific T lymphocytes. |
| Databáze: | OpenAIRE |
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