Hexachlorophene-induced brain edema in rat observed by proton magnetic resonance
| Autor: | Hirohiko Matsumura, Akira Yokota, Hideki Igisu, Yoshimasa Kinoshita |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Hexachlorophene Central nervous system Brain Edema Corpus callosum Corpus Callosum Cerebral edema Diffusion Nuclear magnetic resonance medicine Animals Effective diffusion coefficient Trigeminal Nerve Molecular Biology Trigeminal nerve business.industry General Neuroscience Brain Optic Nerve Anatomy medicine.disease Magnetic Resonance Imaging Rats medicine.anatomical_structure Cerebral cortex Optic nerve Neurology (clinical) Protons business Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 873:127-130 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(00)02523-3 |
| Popis: | Rat brain was examined with 4.7 T proton magnetic resonance (MR). On administering hexachlorophene (HCP) 30 mg/kg/day for 5 days, myelin-rich structures stood out in T2-weighted images. Apparent diffusion coefficient (ADC) was markedly suppressed in all regions examined except for cerebral cortex. Seven days after terminating the exposure to HCP, without enhancement in T2-weighted images, ADC was still decreased in corpus callosum, optic nerve and trigeminal nerve. Rat administered with HCP and followed with high magnetic field proton MR seems to provide a good model for cytotoxic brain edema, and it may also be useful to visualize heavily myelinated structures. |
| Databáze: | OpenAIRE |
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