Haemorrhagic cystitis due to cytomegalovirus in a patient with AIDS

Autor: Sanjay Sadhwani, Adam R. Botha, Sean Doherty, Winston Paul René Padayachee, Alain Mwamba Mukendi, Eunice van den Berg
Rok vydání: 2020
Předmět:
Zdroj: African Journal of Urology, Vol 26, Iss 1, Pp 1-6 (2020)
ISSN: 1961-9987
1110-5704
DOI: 10.1186/s12301-020-00039-4
Popis: Background Cytomegalovirus-related infections are commonly seen in immunocompromised patients. However, haemorrhagic cystitis is an exceptionally rare associated manifestation. We present an unusual case of cytomegalovirus-related haemorrhagic cystitis in a patient with acquired immune deficiency syndrome (AIDS). Case presentation A 33-year-old HIV-positive female presented with acute gross haematuria and suprapubic pain. Cystoscopy revealed features suggestive of haemorrhagic cystitis with clots in the bladder and an ulcerative lesion on the left lateral wall which was biopsied. Histology demonstrated the presence of enlarged cells containing eosinophilic intranuclear and ill-defined amphophilic intracytoplasmic inclusions. Immunohistochemistry was positive for cytomegalovirus. Conclusion This case appears to be the first of its kind reported in South Africa highlighting the importance of considering cytomegalovirus as a potential infectious aetiology in AIDS patients with haematuria. Bladder irrigation with normal saline with or without clot evacuation combined with Ganciclovir are associated with good outcome.
Databáze: OpenAIRE
Externí odkaz: