The concentration of oxazepam and oxazepam glucuronide in oral fluid, blood and serum after controlled administration of 15 and 30 mg oxazepam
| Autor: | Albert Dijkhuizen, Klaas J. Lusthof, Donald R. A. Uges, Antoine C. G. Egberts, Beitske E. Smink, Johan J. de Gier, Berendina J. A. Hofman |
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| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG, Science in Healthy Ageing & healthcaRE (SHARE), Analytical Biochemistry |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Serum Saliva Adolescent Administration Oral Pharmacology AGE Short Reports Pharmacokinetics Predictive Value of Tests Oxazepam glucuronide Oral administration medicine Humans Hypnotics and Sedatives Ingestion Pharmacology (medical) Dosing RISK DISPOSITION oxazepam glucuronide Chemistry Drug Administration Routes oral fluid oxazepam Substance Abuse Detection Treatment Outcome Oxazepam Oral fluid SEX pharmacokinetics medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology, 66(4), 556-560. Wiley |
| ISSN: | 1365-2125 0306-5251 |
| DOI: | 10.1111/j.1365-2125.2008.03252.x |
| Popis: | AIMSTo measure and compare the concentration-time profiles of oxazepam and oxazepam glucuronide in blood, serum and oral fluid within the scope of roadside testing.METHODSBiological samples were collected from eight male subjects after ingestion of 15 or 30 mg oxazepam on separate dosing occasions with an interval of 7 days. The concentration-time profiles of oxazepam and oxazepam glucuronide were fitted by using a one-compartment model.RESULTSFor oxazepam and oxazepam glucuronide, the mean oral fluid/blood ratios were 0.05 (range 0.04-0.07) and 0.004 (range 0.002-0.006), respectively. The concentration-time profiles in oral fluid paralleled those in blood.CONCLUSIONAfter oral administration of therapeutic doses of oxazepam, concentrations in oral fluid are very much lower than those in blood, and those of oxazepam glucuronide are much lower than those of the parent compound. Nevertheless, assay of oral fluid for oxazepam can be used to detect recent ingestion of the drug in drivers suspected of impaired driving performance. |
| Databáze: | OpenAIRE |
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