Altered effective connectivity of primary visual cortex in primary angle closure glaucoma using Granger causality analysis
| Autor: | Yan-Jin Tian, Yu-Lin Zhong, Fei Jiang, Yin-Quan Ye, Xianjun Zeng, Jian-Wen Fang |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Glaucoma Primary angle-closure glaucoma 03 medical and health sciences 0302 clinical medicine Intrinsic brain activity Neuroimaging Ophthalmology medicine Humans Radiology Nuclear Medicine and imaging Visual Cortex Primary (chemistry) Radiological and Ultrasound Technology medicine.diagnostic_test Granger causality analysis business.industry General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Visual cortex medicine.anatomical_structure 030221 ophthalmology & optometry Female Glaucoma Angle-Closure business Functional magnetic resonance imaging 030217 neurology & neurosurgery |
| Zdroj: | Acta Radiologica. 61:508-519 |
| ISSN: | 1600-0455 0284-1851 |
| Popis: | Background Previous neuroimaging studies demonstrated that primary angle closure glaucoma patients were associated with abnormal intrinsic brain activity in primary visual cortex (V1). Purpose The purpose of this study was to investigate the effective connectivity patterns of V1 in patients with primary angle closure glaucoma. Material and Methods Thirty-seven patients with primary angle closure glaucoma (20 men, 17 women) and 36 healthy controls (20 men, 16 women) closely matched for age, sex, and education, underwent resting-state MRI scans. A voxel-wise Granger causality analysis method was performed to explore different effective connectivity pattern of V1 between the two groups. Results Compared with healthy controls, patients with primary angle closure glaucoma showed decreased effective connectivity from the left V1 to left cuneus and increased effective connectivity from the left V1 to left precentral gyrus and right supplementary motor area. Meanwhile, patients with primary angle closure glaucoma showed decreased effective connectivity from left precentral gyrus to left V1 and right frontal middle gyrus to left V1. In addition, patients with primary angle closure glaucoma showed a decreased effective connectivity from the right V1 to left cuneus/calcarine and increased effective connectivity from the right V1 to left inferior frontal gyrus and right caudate. Meanwhile, patients with primary angle closure glaucoma showed decreased effective connectivity from right middle frontal gyrus/precentral gyrus to right V1 and left precentral gyrus to right V1. Conclusion Our results highlighted that patients with primary angle closure glaucoma had abnormal effective connectivity between V1 and higher visual area, motor cortices, somatosensory cortices, and frontal lobe, which indicated that they might present with abnormal top-down modulations, visual imagery, vision-motor function, and vision-related higher cognition function. |
| Databáze: | OpenAIRE |
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