Protective effect of taxifolin against prooxidant and proinflammatory kidney damage associated with acrylamide in rats
| Autor: | Fevzi Bedir, Remzi Arslan, Hüseyin Kocatürk, Renad Mammadov, Durdu Altuner, Abdulkadir Coban, Halis Suleyman, Cebrail Gürsul, Turgut Yapanoglu |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Necrosis Tubular atrophy Interleukin-1beta RM1-950 Pharmacology Kidney Protective Agents Antioxidants Proinflammatory cytokine Nephrotoxicity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Malondialdehyde medicine Animals Taxifolin Rats Wistar Inflammation Acrylamide Tumor Necrosis Factor-alpha General Medicine Kidney damage Glutathione Rats Oxidative Stress 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Rat Kidney Diseases Quercetin Therapeutics. Pharmacology medicine.symptom Reactive Oxygen Species |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 139, Iss, Pp 111660-(2021) |
| ISSN: | 0753-3322 |
| Popis: | The current study investigates the biochemical and histopathological effects of taxifolin on acrylamide-induced kidney damage. A 50 mg/kg dose of taxifolin was administered via oral gavage to the taxifolin + acrylamide (TACR) group (n-6) consisting of male albino Wistar rats. The same volume of distilled water used as solvent was orally administered to the acrylamide (ACR) (n-6) and healthy (HG) (n-6) groups. One hour after the administration of taxifolin and distilled water, a 20 mg/kg dose of acrylamide was orally administered to the TACR and ACR groups. This procedure was repeated once a day for 30 days. In the acrylamide group, malondialdehyde (MDA), tumour necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β) levels were found to be high, total glutathione (tGSH) levels were found to be low, and there was severe interstitial haemorrhage; additionally, tubular necrosis, tubular atrophy, leucocyte infiltration, and glomerular structures with expanded Bowman’s space were observed. In the taxifolin group, where the increase of MDA, IL-1β, and TNF-α and the decrease of tGSH associated with acrylamide have been prevented, any histopathological finding other than mild necrosis and atrophic tubules was not found. This suggests that Taxifolin would prevent kidney tissue from acrylamide-induced damage would be effective in treating acrylamide-induced nephrotoxicity, inhibiting the increase of MDA, IL-1β and TNF-α, and decreasing tGSH associated with acrylamide. |
| Databáze: | OpenAIRE |
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