Uptake of chloroquine and hydroxychloroquine by human blood leucocytes in vitro: relation to cellular concentrations during antirheumatic therapy
| Autor: | W H Betts, J K French, Nigel P. Hurst, M.L. O'Donnell |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Cell Survival
Lymphocyte Immunology In Vitro Techniques Granulocyte Pharmacology Peripheral blood mononuclear cell General Biochemistry Genetics and Molecular Biology Arthritis Rheumatoid Rheumatology Chloroquine Leukocytes medicine Humans Immunology and Allergy business.industry Monocyte Hydroxychloroquine medicine.disease In vitro medicine.anatomical_structure Rheumatoid arthritis business Research Article medicine.drug |
| Zdroj: | Annals of the Rheumatic Diseases. 46:42-45 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.46.1.42 |
| Popis: | The accumulation of chloroquine and hydroxychloroquine in unfractionated mononuclear cells and in purified monocytes, lymphocytes, and neutrophil polymorphonuclear leucocytes (PMN) was measured in vitro. Accumulation of both drugs in leucocytes was time and dose dependent. Cellular levels comparable to those found during antirheumatic therapy were achieved by preincubation for 60 minutes with up to 0.1 mM chloroquine or hydroxychloroquine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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