Impact of uterine manipulator on oncological outcome in endometrial cancer surgery
| Autor: | Padilla-Iserte, Pablo, Lago, Víctor, Tauste, Carmen, Díaz-Feijoo, Berta, Gil-Moreno, Antonio, Oliver, Reyes, Coronado, Pluvio, Martín-Salamanca, María Belén, Pantoja-Garrido, Manuel, Marcos-Sanmartin, Josefina, Gilabert-Estellés, Juan, Lorenzo, Cristina, Cazorla, Eduardo, Roldán-Rivas, Fernando, Rodríguez-Hernández, José Ramón, Sánchez, Lourdes, Muruzábal, Juan Carlos, Hervas, David, Domingo, Santiago, Spanish Society of Gynecology and Obstetrics Spanish Investigational Network Gynecologic Oncology Group |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
recurrence uterine manipulator overall survival medicine.medical_treatment Hysterectomy Disease-Free Survival 03 medical and health sciences oncological safety 0302 clinical medicine endometrial cancer medicine Adjuvant therapy Overall survival Humans Minimally Invasive Surgical Procedures In patient 030212 general & internal medicine recurrence-free survival Stage (cooking) minimally invasive surgery Aged Retrospective Studies 030219 obstetrics & reproductive medicine business.industry Endometrial cancer Obstetrics and Gynecology Retrospective cohort study Middle Aged medicine.disease Uterine manipulator Surgery Endometrial Neoplasms Treatment Outcome Spain Female Neoplasm Recurrence Local business Carcinoma Endometrioid |
| Zdroj: | AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY r-FISABIO. Repositorio Institucional de Producción Científica instname r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante Zaguán. Repositorio Digital de la Universidad de Zaragoza |
| ISSN: | 0002-9378 |
| Popis: | BACKGROUND: There are limited data available to indicate whether oncological outcomes might be influenced by the uterine manipulator, which is used at the time of hysterectomy for minimally invasive surgery in patients with endometrial cancer. The current evidence derives from retrospective studies with limited sample sizes. Without substantial evidence to support its use, surgeons are required to make decisions about its use based only on their personal choice and surgical experience. OBJECTIVE: To evaluate the use of the uterine manipulator on oncological outcomes after minimally invasive surgery, for apparent early-stage endometrial cancer. STUDY DESIGN: We performed a retrospective multicentric study to assess the oncological safety of uterine manipulator use in patients with apparent early-stage endometrial cancer, treated with minimally invasive surgery. The type of manipulator, surgical staging, histology, lymphovascular space invasion, International Federation of Gynecology and Obstetrics stage, adjuvant treatment, recurrence, and pattern of recurrence were evaluated. The primary objective was to determine the relapse rate. The secondary objective was to determine recurrence-free survival, overall survival, and the pattern of recurrence. RESULTS: A total of 2661 women from 15 centers were included; 1756 patients underwent hysterectomy with a uterine manipulator and 905 without it. Both groups were balanced with respect to histology, tumor grade, myometrial invasion, International Federation of Gynecology and Obstetrics stage, and adjuvant therapy. The rate of recurrence was 11.69% in the uterine manipulator group and 7.4% in the no-manipulator group (P |
| Databáze: | OpenAIRE |
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