Synthesis and spin trapping properties of polystyrene supported trifluoromethylated cyclic nitrones
| Autor: | Eric D. Walter, Aruna Earla, Rebecca Braslau |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Biochemistry & Molecular Biology Materials science Free Radicals Radical Photochemistry Biochemistry Medical and Health Sciences Nitrone law.invention 03 medical and health sciences chemistry.chemical_compound Fluorinated law Electron paramagnetic resonance chemistry.chemical_classification nitrone Trifluoromethyl 030102 biochemistry & molecular biology Spin trapping Molecular Structure spin trapping Electron Spin Resonance Spectroscopy General Medicine Biological Sciences polymer supported 030104 developmental biology chemistry Chemical Sciences Polystyrenes Nitrogen Oxides Polystyrene Linker Spin Trapping Polymer supported |
| Zdroj: | Free radical research, vol 53, iss 11-12 |
| Popis: | Polystyrene supported fluorinated cyclic nitrone spin-traps: Resin-2-HFDMPO (2-hydroxymethyl-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole-1-oxide) and Resin-2-PFDMPO (2-(3-hydroxypropyl)-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole 1-oxide) containing a trifluoromethyl pyrroline-N-oxide core were developed to detect free radicals under flow conditions. A continuous flow EPR technique was used to evaluate the spin trapping properties of these tethered nitrones. While both resins trapped radicals, polymer supported nitrone Resin-2-PFDMPO with a longer and more flexible linker showed a more information rich spectrum than Resin-2-HFDMPO. |
| Databáze: | OpenAIRE |
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