Use of libraries to access new chemical space: Applications to CRTH2
| Autor: | Graham Lunn, David Winpenny, M. J. Gardner, M. Abid Masood, Dack Kevin Neil |
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| Rok vydání: | 2012 |
| Předmět: |
Chemistry
Stereochemistry Receptors Prostaglandin Organic Chemistry Clinical Biochemistry Carboxylic Acids Pharmaceutical Science Ligands Biochemistry Combinatorial chemistry Chemical space Small Molecule Libraries Th2 Cells Drug Discovery Humans Molecular Medicine Receptors Immunologic Molecular Biology Protein Binding |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 22:3682-3687 |
| ISSN: | 0960-894X |
| Popis: | The generation of novel CRTH2 ligands in heavily congested chemical space, by de novo design of libraries is disclosed. Novel (1719) compounds across seven libraries were synthesised. More than 100 of these compounds showed binding potency |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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