DENGUE VIRUS. Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers
| Autor: | X.N. Lim, Joanne L. Tan, Aravinda M. de Silva, Kristie D. Ibarra, T.S. Ng, James E. Crowe, Victor A. Kostyuchenko, Eva Harris, Shee-Mei Lok, Guntur Fibriansah, Scott A. Smith, Justin S.G. Ooi, Jiaqi Wang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.drug_class
Viral protein Secondary infection viruses Dengue virus Cross Reactions medicine.disease_cause Monoclonal antibody Serogroup Virus Epitope Article Microbiology Epitopes Mice Viral envelope Viral Envelope Proteins medicine Animals Humans Multidisciplinary biology Coinfection Cryoelectron Microscopy Antibodies Monoclonal Dengue Virus Virology Antibodies Neutralizing Disease Models Animal biology.protein Antibody |
| Zdroj: | Science (New York, N.Y.). 349(6243) |
| ISSN: | 1095-9203 |
| Popis: | An antibody to lock dengue virus out Mosquito-borne dengue virus (DENV) is a growing public health threat. Nearly 400 million people are infected annually, and no vaccine is currently available. Fibriansah et al. report that a human antibody (2D22) specific for DENV serotype 2, when given therapeutically, can protect mice from a lethal form of this virus. Structural analysis revealed that 2D22 binds across multiple DENV envelope proteins, which probably blocks the ability of these proteins to assemble into the orientation necessary for viral entry. The epitope where 2D22 binds to the virus may therefore represent a potential vaccine target. Science , this issue p. 88 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|