Malignant myoepithelioma of the breast (MMB); An interesting case report with pathological, immunohistochemical findings and review of literature
| Autor: | Taha A. Baiomy, Ahmed A. Obaya, Loay M. Gertallah, Ola A. Harb, Sherif Y. Yousif |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty business.industry Rare entity Labeling index Malignancy medicine.disease Pathology and Forensic Medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Malignant Spindle Cell Tumor 030220 oncology & carcinogenesis Malignant Myoepithelioma lcsh:Pathology Medicine Immunohistochemistry Differential diagnosis business Pathological lcsh:RB1-214 |
| Zdroj: | Human Pathology: Case Reports, Vol 17, Iss, Pp-(2019) |
| ISSN: | 2214-3300 |
| Popis: | Background: Malignant myoepithelioma (MMB) of the breast is an extremely rare and aggressive malignant tumor. The biological behavior of such malignancy and treatment outcomes of patients has not been clearly determined. Hypothesis: MMB is morphologically difficult to be distinguished from benign spindle cell proliferations. Identification and further research on the genesis of these tumors could help to discover new molecular targets for its management. Case report: We herein describe the pathological and immunohistochemical characteristics of a case of MMB in a 51 year-old woman to add to the previous data about biological behavior and management strategy of such a rare aggressive entity.We have confirmed the diagnosis of our case using immunohistochemisrty because malignant cells revealed diffuse expression of P63, SMA and S-100 in addition to high Ki-67 labeling index. Conclusions: MMB is extremely rare entity which showed be suspected during differential diagnosis of any malignant spindle cell tumor of the breast. Keywords: Malignant myoepithelioma, Breast, Immunohistochemistry |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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