Low Sensitivity of Conventional Fungal Agars in Fungemia by Rhodotorula Mucilaginosa: Description of Two Cases
| Autor: | María Dolores Moragues, Sara María Quevedo, Jorge Ligero, Carmen Alicia Garcia-Gutiérrez, María José Buitrago, María Soledad Cuétara-García |
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| Přispěvatelé: | Instituto de Salud Carlos III, Basque Government (España), Instituto de Salud Carlos III - ISCIII, Gobierno Vasco |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Microbiological Techniques Microbiology (medical) medicine.medical_specialty Antifungal Agents Antigens Fungal specific culture media lcsh:QR1-502 Case Report Drug resistance lcsh:Microbiology Rhodotorula mucilaginosa lcsh:Infectious and parasitic diseases Microbiology 03 medical and health sciences 0302 clinical medicine Medical microbiology Humans Medicine rhodotorula mucilaginosa risk factors lcsh:RC109-216 030212 general & internal medicine Pathogen Fungemia Aged 80 and over 0303 health sciences Rapid diagnostic test fungemia 030306 microbiology business.industry lcsh:RM1-950 Fungi Rhodotorula General Medicine Middle Aged medicine.disease Culture Media lcsh:Therapeutics. Pharmacology Infectious Diseases Mycoses Parasitology Blood Culture Candida spp business |
| Zdroj: | Addi: Archivo Digital para la Docencia y la Investigación Universidad del País Vasco Addi. Archivo Digital para la Docencia y la Investigación instname Repisalud Instituto de Salud Carlos III (ISCIII) Annals of Clinical Microbiology and Antimicrobials Annals of Clinical Microbiology and Antimicrobials, Vol 20, Iss 1, Pp 1-5 (2021) |
| Popis: | Background Although most bloodstream yeast infections are caused by Candida spp., infections by rare or less common species have increased in recent years. Diagnosis of infections caused by these species is difficult due to the lack of specific symptoms and adequate diagnostic tools. Cases presentation We describe two cases of fungemia by Rhodotorula mucilaginosa within a few months of each other, in a secondary Spanish hospital. In both cases, diagnosis was challenging. Blood subcultures in conventional fungal media were persistently negatives and the use of non-conventional fungal media was essential for isolating the yeasts and achieving a correct diagnosis. 1–3 beta-d-glucan detection and a panfungal PCR assay were helpful techniques to confirm the diagnosis Conclusion It is highly important to establish an early diagnosis for fungemia. The process is challenging because often non-specific symptoms are presents. When yeasts grow in blood cultures other genera than Candida spp. could be the cause of infection. Patient risk factors should be assessed to incorporate alternative culture media and the available rapid diagnostic test, in order to provide an early recognition of the pathogen. |
| Databáze: | OpenAIRE |
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