Pentamidine inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents
| Autor: | J. J. C. Sidrim, D. S. C. M. Castelo-Branco, Jonathas Sales de Oliveira, Zoilo Pires de Camargo, Marcos Fg Rocha, Anderson Messias Rodrigues, Raissa Gp Lopes, Vandbergue Santos Pereira, R. S. N. Brilhante, Waldemiro de Aquino Pereira-Neto, Rossana de Aguiar Cordeiro |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Antifungal Agents Itraconazole Meglumine antimoniate 030106 microbiology Microbial Sensitivity Tests Microbiology 03 medical and health sciences Amphotericin B medicine Sporothrix schenckii skin and connective tissue diseases Pentamidine Microbial Viability Sporotrichosis biology Chemistry Sporothrix Broth microdilution Drug Synergism bacterial infections and mycoses medicine.disease biology.organism_classification Biofilms medicine.drug |
| Zdroj: | Future microbiology. 13 |
| ISSN: | 1746-0921 |
| Popis: | Aim: The purpose of this study was to evaluate the effects of the antileishmanials meglumine antimoniate and pentamidine against Sporothrix schenckii complex. Materials & methods: The antifungal activity of the two antileishmanials was assessed by broth microdilution. The interaction between the antileishmanials and antifungal drugs (amphotericin B, itraconazole and terbinafine) was evaluated by the checkerboard assay. The effect of prior exposure of Sporothrix spp. yeast cells to antileishmanials was evaluated by broth microdilution. Results: Only pentamidine showed antifungal activity against Sporothrix spp. Synergistic interactions were observed between pentamidine and the antifungals. Also, the pre-exposure to meglumine antimoniate reduced the susceptibility of Sardinella brasiliensis and S. schenckii sensu stricto to amphotericin B and itraconazole. Conclusion: Pentamidine showed antifungal activity against Sporothrix spp., indicating it is a possible therapeutic alternative for the treatment of sporotrichosis. |
| Databáze: | OpenAIRE |
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