Head-twitch response induced by ergometrine in mice: behavioural evidence for direct stimulation of central 5-hydroxytryptamine receptors by ergometrine
| Autor: | T. R. Bapat, A G Chandorkar, Nandal Nv, Gada Vp, J J Balsara |
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| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Fenfluramine Methysergide Cyproheptadine Propranolol Head-twitch response Mice Internal medicine medicine Animals Ergometrine P-Chloroamphetamine Ergonovine p-Chloroamphetamine Pharmacology P chlorophenylalanine Dose-Response Relationship Drug Chemistry Fenclonine Endocrinology Receptors Serotonin Clomipramine Stereotyped Behavior medicine.drug |
| Zdroj: | Psychopharmacology. 88(3) |
| ISSN: | 0033-3158 |
| Popis: | Ergometrine (2.5-80 mg/kg IP) induced head twitches in mice. Pretreatment with cyproheptadine (1.5 and 3 mg/kg), methysergide (5 and 10 mg/kg) and (-)-propranolol (2.5 and 5 mg/kg) significantly decreased the number of head twitches induced by ergometrine. Pretreatment with p-chlorophenylalanine (100 mg/kg/day X 4 days) and clomipramine (5 and 10 mg/kg) significantly decreased the number of head twitches induced by fenfluramine (10 mg/kg) and p-chloramphetamine (5 mg/kg) but had no significant effect on the number of head twitches induced by ergometrine. The results indicate that ergometrine induces head twitches in mice by directly stimulating central 5-hydroxytryptamine receptors. |
| Databáze: | OpenAIRE |
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