Improved performance by replacing iminodiacetic residues with glyceryl residues in symmetrically branched oligoglycerols
| Autor: | Ayato Katagiri, Motoo Yamasaki, Hisao Nemoto, Atsushi Ishihara, Takaaki Araki, Yutaka Tomoda, Masaki Kamiya, Tsuyoshi Matsushita, Hatsuhiko Hattori, Yukiteru Mimura |
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| Rok vydání: | 2011 |
| Předmět: |
Glycerol
chemistry.chemical_classification Liposome Molecular Structure Imino acid Stereochemistry Imino Acids Organic Chemistry Clinical Biochemistry Duration period Pharmaceutical Science Stereoisomerism Biochemistry Residue (chemistry) Improved performance chemistry Dendrimer Drug Discovery Molecular Medicine Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 21:4724-4727 |
| ISSN: | 0960-894X |
| Popis: | Synthesis of a symmetrically branched diglycerol (BGL002, involving one iminodiacetic residue) as a G2 dendron, and the tetradecaglycerol (BGL014, involving one iminodiacetic residue) as a G4 dendron, is described. Several members of the BGL family of G2-G4 dendrons were assembled, with G2 bearing four hydroxyl groups at the terminus region, G3 bearing eight, and G4 bearing sixteen. It is noteworthy that triglycerol (BGL003, including no iminodiacetic residue), has a water-solubility ten times higher than BGL002, and the liposome surrounded by BGL014 has a duration period in blood vessel roughly two times longer than the liposome surrounded by dodecaglycerol (BGL012, including three iminodiacetic residues). |
| Databáze: | OpenAIRE |
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