Diabetic Retinopathy Environment-Wide Association Study (EWAS) in NHANES 2005–2008
| Autor: | Sarega Gurudas, Ying Lee, Kevin Blighe, Sobha Sivaprasad |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
National Health and Nutrition Examination Survey lcsh:Medicine 030209 endocrinology & metabolism Article 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine medicine Risk factor 030304 developmental biology 0303 health sciences medicine.diagnostic_test business.industry lcsh:R Univariate Area under the curve circulating biomarkers General Medicine Diabetic retinopathy medicine.disease Regression environment wide association study diabetic retinopathy Liver function tests business hyperglycaemia |
| Zdroj: | Journal of Clinical Medicine, Vol 9, Iss 3643, p 3643 (2020) Journal of Clinical Medicine Volume 9 Issue 11 |
| ISSN: | 2077-0383 |
| Popis: | Several circulating biomarkers are reported to be associated with diabetic retinopathy (DR). However, their relative contributions to DR compared to known risk factors, such as hyperglycaemia, hypertension, and hyperlipidaemia, remain unclear. In this data driven study, we used novel models to evaluate the associations of over 400 laboratory parameters with DR compared to the established risk factors. Methods: we performed an environment-wide association study (EWAS) of laboratory parameters available in National Health and Nutrition Examination Survey (NHANES) 2007&ndash 2008 in individuals with diabetes with DR as the outcome (test set). We employed independent variable (feature) selection approaches, including parallelised univariate regression modelling, Principal Component Analysis (PCA), penalised regression, and RandomForest&trade These models were replicated in NHANES 2005&ndash 2006 (replication set). Our test and replication sets consisted of 1025 and 637 individuals with available DR status and laboratory data respectively. Glycohemoglobin (HbA1c) was the strongest risk factor for DR. Our PCA-based approach produced a model that incorporated 18 principal components (PCs) that had an Area under the Curve (AUC) 0.796 (95% CI 0.761&ndash 0.832), while penalised regression identified a 9-feature model with 78.51% accuracy and AUC 0.74 (95% CI 0.72&ndash 0.77). RandomForest&trade identified a 31-feature model with 78.4% accuracy and AUC 0.71 (95% CI 0.65&ndash 0.77). On grouping the selected variables in our RandomForest&trade hyperglycaemia alone achieved AUC 0.72 (95% CI 0.68&ndash 0.76). The AUC increased to 0.84 (95% CI 0.78&ndash 0.9) when the model also included hypertension, hypercholesterolemia, haematocrit, renal, and liver function tests. |
| Databáze: | OpenAIRE |
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