Low Aromatase Activity and Estradiol/Sex Hormone Binding Globulin Ratio are Associated with Total Hip Bone Mineral Density and the Presence of Osteoporosis: A Study in Chinese Postmenopausal Women
| Autor: | Jie Bai, Fang-Yuan Zhou, Guang-Zhen Zhang, Yan Li, Jun Yan, Hai-Juan Liu, Xu-Dong Su, Hui-jing Fan |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Bone density Endocrinology Diabetes and Metabolism Clinical Biochemistry Osteoporosis 030209 endocrinology & metabolism Biochemistry Bone remodeling 03 medical and health sciences 0302 clinical medicine Endocrinology Sex hormone-binding globulin Aromatase N-terminal telopeptide Asian People Bone Density Internal medicine Sex Hormone-Binding Globulin medicine Prevalence Humans Testosterone Osteoporosis Postmenopausal Aged Bone mineral Likelihood Functions Hip biology Estradiol business.industry Biochemistry (medical) General Medicine Middle Aged medicine.disease Postmenopause Bone Diseases Metabolic 030104 developmental biology ROC Curve biology.protein Linear Models Female Bone Remodeling business Biomarkers |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 50(1) |
| ISSN: | 1439-4286 |
| Popis: | Several groups have reported the important role of estradiol (E2) and testosterone (T) in postmenopausal osteoporosis (PMOP). Because aromatase catalyzes the conversion of T to E2, the purpose of this study was to determine the influence of aromatase activity on the bone mineral density (BMD) in postmenopausal women. A total of 344 postmenopausal women were selected for this study. Serum E2, T, sex hormone-binding globulin (SHBG), calcium (Ca), alkaline phosphatase (ALP), C-terminal telopeptide of type I collagen (CTX), and procollagen type I amino-terminal propeptide (PINP) were examined. The E2/T was positively associated with total hip BMD and PINP (p |
| Databáze: | OpenAIRE |
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