Antagonistic Effects ofGingko bilobaandSophora japonicaon Cerebral Vasoconstriction in Response to Histamine, 5-Hydroxytryptamine, U46619 and Bradykinin
| Autor: | Thanh Van Nguyen, Atsushi Miyamoto, Mitsuya Shiraishi, Cuong Van Dao, Ha Thi Thanh Nguyen, Tuong Manh Nguyen, Md. Zahorul Islam, Pitchaya Pothinuch, Takeshi Obi, Hai Thanh Nguyen |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Ketanserin Swine medicine.drug_class Thromboxane Histamine Antagonists Prostaglandin Bradykinin Flowers In Vitro Techniques 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Extracellular Animals Vasospasm Intracranial Plant Extracts Ginkgo biloba General Medicine Receptor antagonist Plant Leaves 030104 developmental biology Endocrinology Complementary and alternative medicine chemistry Vasoconstriction 15-Hydroxy-11 alpha 9 alpha-(epoxymethano)prosta-5 13-dienoic Acid Basilar Artery Female Serotonin Antagonists medicine.symptom Sophora 030217 neurology & neurosurgery Histamine Phytotherapy medicine.drug |
| Zdroj: | The American Journal of Chinese Medicine. 44:1607-1625 |
| ISSN: | 1793-6853 0192-415X |
| DOI: | 10.1142/s0192415x16500907 |
| Popis: | The aim of this study was to evaluate, for the first time, the antagonistic effects of Gingko biloba leaf (GB) and Sophora japonica L. flower bud (SJ) extracts on cerebral vasoconstriction in response to KCl, extracellular Ca[Formula: see text], histamine, 5-hydroxytryptamine (5-HT), 9,11-dideoxy-9[Formula: see text],11[Formula: see text]-methanoepoxy prostaglandin (PG) F[Formula: see text](U46619) and bradykinin (BK), in order to explain their traditional application for diseases associated with cerebral vasospasm. Isolated porcine basilar arteries (PBA) and endothelial cells from them were used as the study materials. Neither SJ nor GB had any effect on the contractions induced by KCl and extracellular Ca[Formula: see text]. SJ significantly inhibited the contraction induced by histamine, 5-HT, U46619 and BK, whereas GB inhibited histamine-induced contraction, but had no effects on the contractions induced by 5-HT, U46619 and BK. In the presence of diphenhydramine (a H1receptor antagonist), ketanserin (a 5-HT2receptor antagonist) and ONO-3708 (a thromboxane (TX) A2/PG receptor antagonist), the inhibitory effects of these extracts on the contractions induced by histamine, 5-HT and U46619 were abolished. SJ significantly inhibited the contractions induced by BK and PGF[Formula: see text], but in the presence of ONO-3708 (10[Formula: see text] M) had no effect on them. BK enhanced the production of PGF[Formula: see text] from cultured PBA endothelium cells, and SJ significantly attenuated this enhancement. These results suggest that SJ and GB have a H1-antagonistic effect, and that SJ also attenuates cerebral vasoconstriction mediated via 5-HT2and TXA2/PG receptors. These findings appear to explain why SJ has been used traditionally as a therapeutic medication for cerebral vasospasm after cerebral hemorrhage. |
| Databáze: | OpenAIRE |
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