A review on the molecular mechanisms involved in insulin resistance induced by organophosphorus pesticides
| Autor: | Najoua Gharbi, Ines Bini Dhouib, Mohamed Montassar Lasram, Alya Annabi, Saloua El Fazaa |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Inflammation Type 2 diabetes Toxicology Organophosphorus Compounds Insulin resistance Glycation Internal medicine medicine Animals Humans Glucose homeostasis Obesity Pesticides biology Insulin Lipid Metabolism medicine.disease Oxidative Stress Insulin receptor Glucose Endocrinology Lipotoxicity biology.protein Insulin Resistance medicine.symptom Signal Transduction |
| Zdroj: | Toxicology. 322:1-13 |
| ISSN: | 0300-483X |
| DOI: | 10.1016/j.tox.2014.04.009 |
| Popis: | There is increasing evidence reporting that organophosphorus pesticides (OPs) impair glucose homeostasis and cause insulin resistance and type 2 diabetes. Insulin resistance is a complex metabolic disorder that defies explanation by a single etiological pathway. Formation of advanced glycation end products, accumulation of lipid metabolites, activation of inflammatory pathways and oxidative stress have all been implicated in the pathogenesis of insulin resistance. Ultimately, these molecular processes activate a series of stress pathways involving a family of serine kinases, which in turn have a negative effect on insulin signaling. Experimental and clinical data suggest an association between these molecular mechanisms and OPs compounds. It was first reported that OPs induce hyperglycemia. Then a concomitant increase of blood glucose and insulin was pointed out. For some years only, we have begun to understand that OPs promote insulin resistance and increase the risk of type 2 diabetes. Overall, this review outlines various mechanisms that lead to the development of insulin resistance by OPs exposure. |
| Databáze: | OpenAIRE |
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