Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma
| Autor: | Matilda Aakula, Eija Bergroth, James E. Gern, Yury A. Bochkov, Matti Korppi, Carlos A. Camargo, Varpu Elenius, Sami Remes, Tuomas Jartti, Eija Piippo-Savolainen, Pedro A. Piedra |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Rhinovirus Respiratory syncytial virus medicine.disease_cause Asthma development Article HR Hazard ratio 03 medical and health sciences 0302 clinical medicine Influenza A Virus H1N1 Subtype Internal medicine Wheeze Immunology and Allergy Medicine Humans 030212 general & internal medicine Respiratory sounds Prospective Studies Child RV Rhinovirus Finland Asthma Respiratory Sounds Picornaviridae Infections medicine.diagnostic_test Wheezing business.industry Hazard ratio Infant Atopic dermatitis Odds ratio medicine.disease aHR Adjusted hazard ratio 030228 respiratory system Bronchiolitis Child Preschool aOR Adjusted odds ratio RSV Respiratory syncytial virus medicine.symptom business Follow-Up Studies OR Odds ratio |
| Zdroj: | The Journal of Allergy and Clinical Immunology. in Practice The Journal of Allergy and Clinical Immunology: In Practice |
| ISSN: | 2213-2201 2008-2010 |
| Popis: | Background Respiratory syncytial virus (RSV)- and rhinovirus (RV)-induced bronchiolitis are associated with an increased risk of asthma, but more detailed information is needed on virus types. Objective To study whether RSV or RV types are differentially associated with the future use of asthma control medication. Methods Over 2 consecutive winter seasons (2008-2010), we enrolled 408 children hospitalized for bronchiolitis at age less than 24 months into a prospective, 3-center, 4-year follow-up study in Finland. Virus detection was performed by real-time reverse transcription PCR from nasal wash samples. Four years later, we examined current use of asthma control medication. Results A total of 349 (86%) children completed the 4-year follow-up. At study entry, the median age was 7.5 months, and 42% had RSV, 29% RV, 2% both RSV and RV, and 27% non-RSV/-RV etiology. The children with RV-A (adjusted hazard ratio, 2.3; P = .01), RV-C (adjusted hazard ratio, 3.5; P < .001), and non-RSV/-RV (adjusted hazard ratio, 2.0; P = .004) bronchiolitis started the asthma control medication earlier than did children with RSV bronchiolitis. Four years later, 27% of patients used asthma control medication; both RV-A (adjusted odds ratio, 3.0; P = .03) and RV-C (adjusted odds ratio, 3.7; P |
| Databáze: | OpenAIRE |
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