Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia : a sub analysis of the PRIZE Study
| Autor: | Yuichi Akasaki, Kenya Kusunose, Kazuo Eguchi, Hirotsugu Yamada, Masataka Sata, Prize Study Investigators, Yoshihiro Fukumoto, Haruo Kamiya, Hiroki Teragawa, Koichi Node, Atsushi Tanaka, Kazuomi Kario, Hisako Yoshida |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty Physiology Awards and Prizes Diastole hyperuricemia Asymptomatic Article Ventricular Function Left Ventricular Dysfunction Left Internal medicine Natriuretic Peptide Brain Troponin I Internal Medicine medicine Clinical endpoint Humans echocardiography Hyperuricemia Randomized Controlled Trials as Topic Heart Failure business.industry febuxostat diastolic function Stroke Volume medicine.disease Brain natriuretic peptide NT-proBNP Cardiology Febuxostat medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Hypertension Research |
| ISSN: | 0916-9636 |
| Popis: | Hyperuricemia is related to an increased risk of cardiovascular events from a meta-analysis and antihyperuricemia agents may influence to cardiac function. We evaluated the effect of febuxostat on echocardiographic parameters of diastolic function in patients with asymptomatic hyperuricemia as a prespecified endpoint in the subanalysis of the PRIZE study. Patients in the PRIZE study were assigned randomly to either add-on febuxostat treatment group or control group with only appropriate lifestyle modification. Of the 514 patients in the overall study, 65 patients (31 in the febuxostat group and 34 in the control group) who had complete follow-up echocardiographic data of the ratio of peak early diastolic transmitral flow velocity (E) to peak early diastolic mitral annular velocity (e′) at baseline and after 12 and 24 months were included. The primary endpoint was a comparison of the changes in the E/e′ between the two groups from baseline to 24 months. Interestingly, e′ was slightly decreased in the control group compared with in the febuxostat group (treatment p = 0.068, time, p = 0.337, treatment × Time, p = 0.217). As a result, there were significant increases in E/e′ (treatment p = 0.045, time, p = 0.177, treatment × time, p = 0.137) after 24 months in the control group compared with the febuxostat group. There was no significant difference in the serum levels of N-terminal-pro brain natriuretic peptide and high-sensitive troponin I between the two groups during the study period. In conclusions, additional febuxostat treatment in patients with asymptomatic hyperuricemia for 24 months might have a potential of preventable effects on the impaired diastolic dysfunction. |
| Databáze: | OpenAIRE |
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