Helicobacter pylori infection as a potential risk factor for multiple sclerosis
| Autor: | Georgia Deretzi, Michael Doulberis, Emmanuel Gavalas, Christos Liatsos, Panagiotis Katsinelos, Panagiota Kyriakou, Apostolis Papaefthymiou, Dimitri Tzivras, Elisabeth Vardaka, Maria Tzitiridou-Chatzopoulou, Marina Boziki, Stergios A. Polyzos, Jannis Kountouras, Christos Zavos, Efthymios Dardiotis |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Multiple Sclerosis Helicobacter Infections Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Risk Factors medicine Humans Clinically isolated syndrome Helicobacter pylori biology Chronic Active business.industry Multiple sclerosis Experimental autoimmune encephalomyelitis General Medicine medicine.disease biology.organism_classification 030104 developmental biology Gastric Mucosa Gastritis Immunology medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Medical Hypotheses. 143:110135 |
| ISSN: | 0306-9877 |
| DOI: | 10.1016/j.mehy.2020.110135 |
| Popis: | Helicobacter pylori infection (Hp-I) has been associated with a wide spectrum of gastrointestinal and extra-digestive manifestations, including neurodegenerative diseases. Contradictory data have been published on Hp-I and multiple sclerosis (MS) association, with studies mainly using serology for Hp-I detection that cannot distinguish between active and past infections. We herein hypothesize that humoral and cellular immune responses induced by active Hp-I, beyond damaging locally the gastric mucosa, they may shape the character of systemic autoimmune responses, contributing to MS pathogenesis. To investigate our hypothesis, active Hp-I has been diagnosed in two small MS Greek cohorts by using primarily gastric mucosa histology. A higher prevalence of active Hp-I was documented in MS patients vs. controls (86.4 vs. 50%, P = 0.002) accompanied by exclusive existence of duodenal ulcer and autoimmune diseases with endoscopic and histological findings of chronic active gastritis for the MS group. Our preliminary data suggested that active Hp-I unlike other studies, may not protect, but contribute to MS and we proposed possible Hp-relating mechanisms involved in MS pathophysiology, that merit further evaluation. |
| Databáze: | OpenAIRE |
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