Extra-cellular expansion in the normal, non-infarcted myocardium is associated with worsening of regional myocardial function after acute myocardial infarction

Autor: Philip Haaf, R.J. van der Geest, Peter P Swoboda, Laura E Dobson, John P Greenwood, Tarique A Musa, Adam K McDiarmid, Pei G. Chew, Sven Plein, David A. Broadbent, Pankaj Garg, Ananth Kidambi, Graham J. Fent, David P Ripley, James R. J. Foley, Saul Crandon, Bara Erhayiem
Rok vydání: 2017
Předmět:
Male
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
media_common.quotation_subject
Heart Ventricles
CT and MRI
Myocardial Infarction
Acute myocardial infarction
030204 cardiovascular system & hematology
030218 nuclear medicine & medical imaging
03 medical and health sciences
Ventricular Dysfunction
Left
0302 clinical medicine
Fibrosis
Internal medicine
Edema
Extracellular fluid
Cardiovascular imaging agents/techniques
medicine
Humans
Radiology
Nuclear Medicine and imaging
Myocardial infarction
cardiovascular diseases
Prospective Studies
Angiology
media_common
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
Convalescence
Myocardium
Research
Electrocardiography in myocardial infarction
Magnetic resonance imaging
Heart
Extracellular matrix
Middle Aged
medicine.disease
Magnetic Resonance Imaging
United Kingdom
lcsh:RC666-701
Cardiology
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Zdroj: Journal of Cardiovascular Magnetic Resonance
Journal of Cardiovascular Magnetic Resonance, Vol 19, Iss 1, Pp 1-13 (2017)
Journal of Cardiovascular Magnetic Resonance, 19
ISSN: 1532-429X
1097-6647
Popis: Background Expansion of the myocardial extracellular volume (ECV) is a surrogate measure of focal/diffuse fibrosis and is an independent marker of prognosis in chronic heart disease. Changes in ECV may also occur after myocardial infarction, acutely because of oedema and in convalescence as part of ventricular remodelling. The objective of this study was to investigate changes in the pattern of distribution of regional (normal, infarcted and oedematous segments) and global left ventricular (LV) ECV using semi-automated methods early and late after reperfused ST-elevation myocardial infarction (STEMI). Methods Fifty patients underwent cardiovascular magnetic resonance (CMR) imaging acutely (24 h–72 h) and at convalescence (3 months). The CMR protocol included: cines, T2-weighted (T2 W) imaging, pre−/post-contrast T1-maps and LGE-imaging. Using T2 W and LGE imaging on acute scans, 16-segments of the LV were categorised as normal, oedema and infarct. 800 segments (16 per-patient) were analysed for changes in ECV and wall thickening (WT). Results From the acute studies, 325 (40.6%) segments were classified as normal, 246 (30.8%) segments as oedema and 229 (28.6%) segments as infarct. Segmental change in ECV between acute and follow-up studies (Δ ECV) was significantly different for normal, oedema and infarct segments (0.8 ± 6.5%, −1.78 ± 9%, −2.9 ± 10.9%, respectively; P
Databáze: OpenAIRE
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