Aqueous Extracts of Lippia turbinata and Aloysia citriodora (Verbenaceae): Assessment of Antioxidant Capacity and DNA damage
| Autor: | Claudia Reides, Rafael A. Ricco, Marcelo L. Wagner, Marta A. Carballo, Susana Llesuy, Marcela M. López Nigro, Erika Portmann, Alberto A. Gurni |
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| Rok vydání: | 2012 |
| Předmět: |
Antioxidant
Mitotic index DNA damage medicine.medical_treatment Decoction Toxicology Thiobarbituric Acid Reactive Substances Antioxidants Lipid peroxidation chemistry.chemical_compound Verbenaceae Mitotic Index medicine Animals Humans Lymphocytes Rats Wistar Cells Cultured Cell Proliferation Flavonoids Micronucleus Tests Plants Medicinal Traditional medicine Aloysia biology Plant Extracts Brain Polyphenols Plant Components Aerial biology.organism_classification Rats Biochemistry chemistry Luminescent Measurements Micronucleus test Female Comet Assay Sister Chromatid Exchange Tannins DNA Damage |
| Zdroj: | International Journal of Toxicology. 31:192-202 |
| ISSN: | 1092-874X 1091-5818 |
| DOI: | 10.1177/1091581812436726 |
| Popis: | The aim of the present work was to make a contribution to the knowledge of aqueous extracts of Lippia turbinata and Aloysia citriodora (Verbenaceae; infusion and decoction) in relation with the establishment of its antioxidant activity and lack of DNA damage, for its potential use in therapeutics. The cytogenotoxic profile was evaluated through genotoxic biomarkers such as mitotic index, cellular proliferation kinetics, sister chromatid exchanges, single-cell gel electrophoresis assay, and micronucleus test in human peripheral blood lymphocyte cultures. No statistical differences were found ( P > .05) between control and exposed cultures, even between both aqueous extracts. The total antioxidant capacity was shown to be higher in the decoction than in the infusion and both aqueous extracts protected against protein carbonylation and lipid peroxidation, the decoction being more efficient than the infusion ( P < .005). These results suggest the safe use of these medicinal plants as chemoecologic agents in therapeutics. |
| Databáze: | OpenAIRE |
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