Polycyclic Aromatic Hydrocarbons Alter the Hepatic Expression of Genes Involved in Sanderling ( Calidris alba ) Pre‐migratory Fueling
| Autor: | Amani Farhat, Christy A. Morrissey, Kristin Bianchini, Doug Crump |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
021110 strategic
defence & security studies food.ingredient Chemistry Health Toxicology and Mutagenesis 0211 other engineering and technologies 02 engineering and technology 010501 environmental sciences Pah exposure 01 natural sciences Molecular biology Fatty acid-binding protein Charadriiformes Calidris food Liver Gene expression Animals Environmental Chemistry Hepatic lipase Polycyclic Aromatic Hydrocarbons Deposition (chemistry) Gene 0105 earth and related environmental sciences |
| Zdroj: | Environmental Toxicology and Chemistry. 40:1981-1989 |
| ISSN: | 1552-8618 0730-7268 |
| Popis: | Polycyclic aromatic hydrocarbons (PAHs) impaired pre-migratory fueling in 49 orally dosed Sanderling (Calidris alba). In the present study, 8 genes related to fat deposition and PAH exposure were measured in liver subsamples from these same shorebirds. At the highest dose (1260 µg total PAH [tPAH]/kg body wt/day), PAH exposure decreased liver basic fatty acid binding protein 1 (Lbfabp) and hepatic lipase (Lipc) expression. The present study reveals candidate molecular-level pathways for observed avian pre-migratory refueling impairment. Environ Toxicol Chem 2021;40:1983-1991. © 2021 SETAC. |
| Databáze: | OpenAIRE |
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