Role of the endocannabinoid system in vertebrates: Emphasis on the zebrafish model
| Autor: | Su Guo, Adam Melgoza, Brian Nguyen, Francesca Oltrabella |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Nervous system Cannabinoid receptor ved/biology.organism_classification_rank.species Pharmacology Cannabis sativa Article 03 medical and health sciences chemistry.chemical_compound biology.animal medicine Animals Dronabinol Receptors Cannabinoid Model organism Zebrafish biology ved/biology Vertebrate Cell Biology Anandamide biology.organism_classification Endocannabinoid system 030104 developmental biology medicine.anatomical_structure chemistry Neuroscience Endocannabinoids Developmental Biology |
| Zdroj: | Development, Growth & Differentiation. 59:194-210 |
| ISSN: | 0012-1592 |
| DOI: | 10.1111/dgd.12351 |
| Popis: | The endocannabinoid system (eCBs), named after the plant Cannabis sativa, comprises cannabinoid receptors, endogenous ligands known as “endocannabinoids”, and enzymes involved in the biosynthesis and degradation of these ligands, as well as putative transporters for these ligands. ECBs proteins and small molecules have been detected in early embryonic stages of many vertebrate models. As a result, cannabinoid receptors and endogenous as well as exogenous cannabinoids influence development and behavior in many vertebrate species. Understanding the precise mechanisms of action for the eCBs will provide an invaluable guide towards elucidation of vertebrate development and will also help delineate how developmental exposure to marijuana might impact health and cognitive and executive functioning in adulthood. Here we review the developmental roles of the eCBs in vertebrates, focusing our attention on the zebrafish model. Since little is known regarding the eCBs in zebrafish, we provide new data on the expression profiles of eCBs genes during development and in adult tissue types of this model organism. We also highlight exciting areas for future investigations, including the synaptic regulation of eCBs, its role in reward and addiction, and in nervous system development and plasticity. |
| Databáze: | OpenAIRE |
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