Unusual case of inflammatory spinal epidural mass (Castleman Syndrome)
| Autor: | Gülay Alper, Ellen R. Wald, Ronald L. Hamilton, A. Leland Albright, Patricia K. Crumrine |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Epidural Space
Male Pathology medicine.medical_specialty Lymphoma Anemia Malignancy Diagnosis Differential Pathogenesis Developmental Neuroscience medicine Humans Child Leg Muscle Weakness business.industry Castleman Disease Headache Hypergammaglobulinemia Spinal cord medicine.disease Magnetic Resonance Imaging Lymphocyte Subsets medicine.anatomical_structure Neurology Pediatrics Perinatology and Child Health Etiology Histopathology Neurology (clinical) Complication business Spinal Cord Compression Plasmacytoma |
| Zdroj: | Pediatric Neurology. 15:60-62 |
| ISSN: | 0887-8994 |
| DOI: | 10.1016/0887-8994(96)00090-2 |
| Popis: | Castleman syndrome (giant lymph node hyperplasia) is a rare, heterogeneous lymphoproliferative disorder of unknown etiology and pathogenesis. Most cases occur as mediastinal masses, although extrathoracic involvement including nodal and extranodal locations have been reported. The localized variants (solitary lesions) respond well to surgical excision. We report a 10-year-old boy who presented with headache, intermittent fever, and progressive weakness of his legs. MRI imaging showed an enhancing epidural mass with impingement on the spinal cord at the C6-T2 level. Other laboratory abnormalities included anemia, hypergammaglobulinemia, increased erythrocyte sedimentation rate, and cerebrospinal fluid pleocytosis with slightly increased cerebrospinal protein. The mass was partially resected and the histopathology showed lymphoplasmocytic infiltration compatible with Castleman syndrome. There was no evidence of malignancy. Castleman syndrome is the most likely diagnosis in the presence of the associated systemic findings, although the epidural site for lymphoplasmocytic inflammation is atypical. |
| Databáze: | OpenAIRE |
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