Cyclo(Pro-DOPA), a third identified bioactive metabolite produced by Streptomyces sp. 8812
| Autor: | Joanna Jarosz, Joanna Ziemska, Dorota Gudanis, Joanna Wietrzyk, Katarzyna Jakubiec-Krzesniak, Aleksandra Rajnisz-Mateusiak, Dorota Kaczorek, Robert Kawęcki, Jolanta Solecka, Adam Guspiel |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antifungal Antifungal Agents medicine.drug_class Stereochemistry Chemical structure Metabolite 030106 microbiology Carboxypeptidases Diketopiperazines Streptomyces 03 medical and health sciences chemistry.chemical_compound Bioactive metabolite Drug Discovery medicine Pharmacology Dipeptide biology Bacteria Chemistry Fungi Dipeptides biology.organism_classification Anti-Bacterial Agents Fermentation Peptidyl Transferases |
| Zdroj: | The Journal of antibiotics. 71(8) |
| ISSN: | 1881-1469 |
| Popis: | A new metabolite, cyclic dipeptide, cis-(3S,8aS)-3-(3,4-dihydroxybenzyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, named JS-3 was isolated from Streptomyces sp. 8812 fermentation broth. Its chemical structure was established by means of spectroscopic analysis. A wide-range-screening study, which included inhibition assay of DD-carboxypeptidase/transpeptidase activity, determination of antibacterial, antifungal, and antiproliferative activities as well as free-radical scavenging was performed. To authors knowledge, this is the first isolation of such compound from natural sources and the first one from bacteria, Streptomyces. |
| Databáze: | OpenAIRE |
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