Antitumor Agents, 145. Cytotoxic Asprellic Acids A and C and Asprellic Acid B, New p-Coumaroyl Triterpenes, from Ilex asprella
| Autor: | Kuo Hsuing Lee, De Cheng Zhang, Hsien Chang Chang, Chang Ming Cheng, Jer Jang Chang, Hsien Tsung Chen, Yoshiki Kashiwada, Yuh Pan Chen |
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| Rok vydání: | 1993 |
| Předmět: |
Coumaric Acids
Stereochemistry Pharmaceutical Science Adenocarcinoma KB Cells Analytical Chemistry Terpene Mice Triterpene Drug Discovery Tumor Cells Cultured Ilex asprella Animals Humans Oleanolic Acid Cytotoxicity Melanoma Gastrointestinal Neoplasms Pharmacology chemistry.chemical_classification Plants Medicinal Leukemia P388 Chemistry Organic Chemistry Biological activity Antineoplastic Agents Phytogenic Terpenoid In vitro Complementary and alternative medicine Cell culture Carcinoma Squamous Cell Molecular Medicine Drug Screening Assays Antitumor |
| Zdroj: | Journal of Natural Products. 56:2077-2082 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | Three new p-coumaroyl triterpenes, asprellic acids A [1], B [2], and C [3], were isolated from the EtOH extract of dried leaves of Ilex asprella. The structures for 1-3 have been established as 3,27-di-O-trans-p-coumaroyl [1], 3-O-trans-p-coumaroyl-27-O-cis-p-coumaroyl- [2], and 3-O-cis-p-coumaroyl-27-O-trans-p-coumaroyl- [3] 3 beta,27-dihydroxyolean-12-en-28-oic acid, respectively, by spectral and chemical examinations. Asprellic acid A [1] exhibited potent cytotoxicity against the RPMI-7951 cell line with an ED50 value of 0.62 micrograms/ml, while the cytotoxicity of asprellic acid C [3] against RPMI-7951 was marginal (ED50 5.5 micrograms/ml). Compounds 1 and 3 also showed cytotoxicity against KB cells with ED50 values of 3.75 and 2.86 micrograms/ml, respectively. Asprellic acid B [2] did not show cytotoxicity (> 10 micrograms/ml) against KB or RPMI-7951 cell lines. |
| Databáze: | OpenAIRE |
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