Dynamic Contrast-Enhanced MRI Perfusion Parameters as Imaging Biomarkers of Angiogenesis
Autor: | Hyunyong Lee, Ahwon Lee, Min Sun Jin, Hyun-bin kim, Bong Joo Kang, Sung Hun Kim, Hyeon Sil Lee, Byung Joo Song |
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Rok vydání: | 2016 |
Předmět: |
Vascular Endothelial Growth Factor A
Pathology Physiology Angiogenesis Tumor Physiology Invasive Ductal Carcinoma Vascular Permeability Contrast Media lcsh:Medicine Vascular permeability Cardiovascular Physiology Biochemistry Vascular Medicine Diagnostic Radiology 030218 nuclear medicine & medical imaging chemistry.chemical_compound Endocrinology 0302 clinical medicine Breast Tumors Basic Cancer Research Medicine and Health Sciences Breast MRI lcsh:Science skin and connective tissue diseases Staining Multidisciplinary Neovascularization Pathologic medicine.diagnostic_test Radiology and Imaging Cell Staining Middle Aged Prognosis Magnetic Resonance Imaging Carcinoma Ductal Perfusion Vascular endothelial growth factor Oncology Tumor Angiogenesis 030220 oncology & carcinogenesis Dynamic contrast-enhanced MRI Research Article Adult medicine.medical_specialty Imaging Techniques Research and Analysis Methods Carcinomas 03 medical and health sciences Diagnostic Medicine Growth Factors medicine Humans Aged Tumor microenvironment Endocrine Physiology business.industry lcsh:R Biology and Life Sciences Cancers and Neoplasms Magnetic resonance imaging Image Enhancement chemistry Specimen Preparation and Treatment lcsh:Q business Biomarkers Developmental Biology |
Zdroj: | PLoS ONE, Vol 11, Iss 12, p e0168632 (2016) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Hypoxia in the tumor microenvironment is the leading factor in angiogenesis. Angiogenesis can be identified by dynamic contrast-enhanced breast MRI (DCE MRI). Here we investigate the relationship between perfusion parameters on DCE MRI and angiogenic and prognostic factors in patients with invasive ductal carcinoma (IDC). Perfusion parameters (Ktrans, kep and ve) of 81 IDC were obtained using histogram analysis. Twenty-fifth, 50th and 75th percentile values were calculated and were analyzed for association with microvessel density (MVD), vascular endothelial growth factor (VEGF) and conventional prognostic factors. Correlation between MVD and ve50 was positive (r = 0.33). Ktrans50 was higher in tumors larger than 2 cm than in tumors smaller than 2 cm. In multivariate analysis, Ktrans50 was affected by tumor size and MVD with 12.8% explanation. There was significant association between Ktrans50 and tumor size and MVD. Therefore we conclude that DCE MRI perfusion parameters are potential imaging biomarkers for prediction of tumor angiogenesis and aggressiveness. |
Databáze: | OpenAIRE |
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