Adaptive Expansion of Taste Neuron Response Profiles by Congruent Aroma in Drosophila
| Autor: | Yan Zhang, Yiwen Zhang, Haini N. Cai, Ping Shen, Yuhan Pu |
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| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Taste biology Chemistry media_common.quotation_subject food and beverages Sensory system Appetite Stimulation biology.organism_classification 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Odor medicine Axon Neuroscience Drosophila 030217 neurology & neurosurgery Aroma 030304 developmental biology media_common |
| DOI: | 10.1101/859223 |
| Popis: | Pairing of food aroma with selected taste can lead to enhanced food flavor and eating euphoria, but how cross-modal sensory combinations are integrated to increase food reward value remains largely unclear. Here we report that combined stimulation by food aroma and taste drastically increased appetite in well-nourished Drosophila larvae, and the appetizing effect involves a previously uncharacterized smell-taste integration process at axon terminals of two Gr43a gustatory neurons. Molecular genetic analyses of the smell-taste integration reveal a G protein-mediated tuning mechanism in two central neuropeptide F (NPF) neurons. This mechanism converts selected odor stimuli to NPF-encoded appetizing signals that potentiate Gr43a neuronal response to otherwise non-stimulating glucose or oleic acid. Further, NPF-potentiated responses to glucose and oleic acid require a Gr43a-independent and Gr43a-dependent pathway, respectively. Our finding of adaptive expansion of taste neuron response profiles by congruent aroma reveals a previously uncharacterized layer of neural complexity in food flavor perception. |
| Databáze: | OpenAIRE |
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