Left ventricular diastolic dysfunction without left ventricular hypertrophy in obese children and adolescents: a Tissue Doppler Imaging and Cardiac Troponin I Study
| Autor: | Maysoun M Al Musaddar, Marwa F Mira, Antoine Fakhry AbdelMassih, Sahar A. Sharaf, Rania El Kaffas, Ihab Hany Barsoum, Sonia A El Saiedi |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Pediatric Obesity Adolescent Diastole 030204 cardiovascular system & hematology Doppler echocardiography Left ventricular hypertrophy Doppler imaging Ventricular Function Left Body Mass Index 03 medical and health sciences Ventricular Dysfunction Left 0302 clinical medicine Internal medicine Troponin I Medicine Humans 030212 general & internal medicine Child medicine.diagnostic_test business.industry General Medicine medicine.disease Echocardiography Doppler medicine.anatomical_structure Cross-Sectional Studies Ventricle Case-Control Studies Pediatrics Perinatology and Child Health Multivariate Analysis Cardiology Female Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine business Lipid profile Body mass index |
| Zdroj: | Cardiology in the young. 28(1) |
| ISSN: | 1467-1107 1047-9511 |
| Popis: | BackgroundObesity increases the risk for various cardiovascular problems. Increase in body mass index is often an independent risk factor for the development of elevated blood pressure and clustering of various cardiovascular risk factors.ObjectiveTo determine early markers of left ventricular affection in obese patients before the appearance of left ventricular hypertrophy.MethodsIn this cross-sectional study, we evaluated 42 obese patients and 30 healthy controls. Their ages ranged from 6 to 19 years. Studied children were subjected to anthropometric, lipid profile, and serum Troponin I level measurements. Echocardiographic evaluation performed to assess the left ventricle included left ventricular dimension measurement using motion-mode echocardiography, based on which patients with left ventricular hypertrophy (10 patients) were eliminated, as well as conventional and tissue Doppler imaging.ResultsTissue Doppler findings in the study groups showed that the ratio of transmitral early diastolic filling velocity to septal peak early diastolic myocardial velocity (E/e′) was significantly higher in cases compared with controls [6.9±1.4 versus 9.0±1.6, p (Pearson’s coefficient)=0.001, respectively]. The level of cardiac troponin I was significantly higher in cases compared with controls [0.14±0.39 ng/ml versus 0.01±0.01 ng/ml, p (Pearson’s coefficient)=0.047, respectively] and there was a significant correlation between troponin I and transmitral early diastolic filling velocity to septal peak early diastolic myocardial velocity ratio (E/e′) [R (correlation coefficient)=0.6].ConclusionTissue Doppler Imaging and Troponin I evaluation proved useful tools to detect early affection of the left ventricle in obese patients even in the absence of left ventricular hypertrophy. |
| Databáze: | OpenAIRE |
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