3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor

Autor:	Michael P. DeNinno, John B. Etienne, Jeanene E. Tickner, Kenneth J. DiRico, W. Ross Tracey, Roger J. Hill, Scott P. Kennedy, Jimmy Kong, Lois K. Chenard, Cynthia Eller, Hiroko Masamune, Joseph J. Oleynek, Delvin R. Knight
Rok vydání:	2003
Předmět:	Agonist Adenosine medicine.drug_class Chemistry Receptor Adenosine A3 Carboxamide Isoxazoles Adenosine A3 receptor Adenosine receptor Chemical synthesis Amides Cell Line Structure-Activity Relationship Biochemistry Drug Discovery medicine Purinergic P1 Receptor Agonists Molecular Medicine Humans Nucleoside Adenosine A2B receptor medicine.drug
Zdroj:	Journal of medicinal chemistry. 46(3)
ISSN:	0022-2623
Popis:	Selective adenosine A(3) agonists have potential utility for the prevention of perioperative myocardial ischemic injury. Herein, we report on the discovery and synthesis of compound 7. This amino nucleoside agonist possesses unprecedented levels of selectivity for the human adenosine A(3) receptor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97fe97d36c3f1729a7fcc3618cbf2430 https://pubmed.ncbi.nlm.nih.gov/12540233 Zobrazit plný text záznamu