HIV Type 1 subtype C remains the predominant subtype in men having sex with men in Senegal
| Autor: | Halimatou Diop Ndiaye, Souleymane Mboup, Coumba Toure-Kane, Ousseynou Ndiaye, Abdou K. Diop, Martine Peeters, Edmond Tchiakpe, Nicole Vidal |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Adolescent Genotype Immunology Human immunodeficiency virus (HIV) HIV Infections Biology medicine.disease_cause gag Gene Products Human Immunodeficiency Virus Men who have sex with men Young Adult Virology Prevalence medicine Humans Men having sex with men Homosexuality Male Phylogeny Molecular Epidemiology Genetic diversity Base Sequence Phylogenetic tree Sequence Analysis RNA Transmission (medicine) env Gene Products Human Immunodeficiency Virus Genetic Variation Senegal Infectious Diseases pol Gene Products Human Immunodeficiency Virus HIV-1 Female |
| Popis: | HIV-1 epidemics are expanding among men who have sex with men in low- and middle-income countries. To confirm and further explore preliminary data in Senegal, we aimed to determine 3 years after a first study the HIV-1 genetic diversity in three different viral regions. From 109 samples available in 2007, 93 were sequenced in gag, 77 in env, and 60 in pol. Phylogenetic analysis showed that subtype C predominated (38–52%), followed by CRF02_AG (30–40%), subtype B (13–17%), and CRF09_cpx (2.6–5%). Subsubtype A3 and strains tightly linked to CRF43_02G were identified in env and gag, respectively, and 12% of the samples were unique recombinants. Six transmission chains involving two to seven individuals were identified. Some strains carried resistance mutations inside transmission chains. This study confirmed the existence of a dual epidemic in Senegal and emphasized the need to strengthen prevention programs to avoid strains intermixing between low-risk women and high-risk men. |
| Databáze: | OpenAIRE |
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