Telomere shortening and telomerase activity in ischaemic cardiomyopathy patients - Potential markers of ventricular arrhythmia
| Autor: | Mehul Dhinoja, Atholl Johnston, Maria Harbo, Steven R. Coppen, Laila Bendix, Chiho Ikebe, Vinit Sawhney, Niall G. Campbell, Yusuke Shintani, Ross J. Hunter, Ken Suzuki, Simon Sporton, Scott Brouilette, Richard J. Schilling, Mark J. Earley, Victoria Baker |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Telomerase medicine.medical_treatment Myocardial Ischemia 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Journal Article Humans Myocardial infarction Prospective cohort study Telomere Shortening Aged Retrospective Studies Aged 80 and over Ejection fraction business.industry Research Support Non-U.S. Gov't Case-control study Retrospective cohort study Middle Aged Implantable cardioverter-defibrillator medicine.disease Telomere Defibrillators Implantable Enzyme Activation 030104 developmental biology Cross-Sectional Studies Case-Control Studies Cardiology Tachycardia Ventricular Female Cardiology and Cardiovascular Medicine business Cardiomyopathies Biomarkers |
| Zdroj: | Sawhney, V, Campbell, N G, Brouilette, S W, Coppen, S R, Harbo, M, Baker, V, Ikebe, C, Shintani, Y, Hunter, R J, Dhinoja, M, Johnston, A, Earley, M J, Sporton, S, Bendix, L, Suzuki, K & Schilling, R J 2016, ' Telomere shortening and telomerase activity in ischaemic cardiomyopathy patients : Potential markers of ventricular arrhythmia ', International Journal of Cardiology, vol. 207, pp. 157-163 . https://doi.org/10.1016/j.ijcard.2016.01.066 |
| ISSN: | 1874-1754 |
| DOI: | 10.1016/j.ijcard.2016.01.066 |
| Popis: | BACKGROUND: Implantable cardioverter defibrillators (ICDs) reduce mortality in patients with ischaemic cardiomyopathy at high risk of ventricular arrhythmias (VA). However, the current indication for ICD prescription needs improvement. Telomere and telomerase in leucocytes have been shown to associate with biological ageing and pathogenesis of cardiovascular diseases. We hypothesised that leucocyte telomere length, load-of-short telomeres and/or telomerase activity are associated with VA occurrence in ischaemic cardiomyopathy patients.METHODS AND RESULTS: 90 ischaemic cardiomyopathy patients with primary prevention ICDs were recruited. 35 had received appropriate therapy from the ICD for potentially-fatal VA while the remaining 55 patients had not. No significant differences in baseline demographic data relevant to telomere biology were seen between the two groups. There was no significant difference in the age and sex adjusted mean telomere length analysed by qPCR between the groups (p=0.88). In contrast, the load-of-short telomeres assessed by Universal-STELA method and telomerase activity by TRAP assay were both higher in patients who had appropriate ICD therapy and were significantly associated with incidence of ICD therapy (p=0.02, p=0.02). ROC analyses demonstrated that the sensitivity and specificity of these telomere dynamics in predicting potentially-fatal VA was higher than the current gold-standard - left ventricular ejection fraction (AUC 0.82 versus 0.47).CONCLUSION: The load-of-short telomeres and telomerase activity had a significant association with ICD therapy (for VA) in ischaemic cardiomyopathy patients. These biomarkers should be tested in prospective studies to assess their clinical utility in predicting VA after myocardial infarction and guiding primary prevention ICD prescription. |
| Databáze: | OpenAIRE |
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