Blockade of 5-Ht3 receptors in the septal area increases Fos expression in selected brain areas
| Autor: | Hilda Silva Ferreira, Lilia S. Urzedo-Rodrigues, C.P. Luz, Rejane Conceição Santana, Camila F. Perrone, Josmara Bartolomei Fregoneze |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Blood Pressure Cell Count Pressoreceptors Biology Amygdala Cellular and Molecular Neuroscience Heart Rate Autonomic Denervation medicine Animals Serotonin 5-HT3 Receptor Antagonists Lateral parabrachial nucleus Rats Wistar Dorsomedial hypothalamic nucleus Cell Nucleus Endocrine and Autonomic Systems Solitary tract Brain Rostral ventrolateral medulla Baroreflex Ondansetron Rats Preoptic area Stria terminalis medicine.anatomical_structure nervous system Hypothalamus Septum of Brain Neurology (clinical) Receptors Serotonin 5-HT3 Proto-Oncogene Proteins c-fos Neuroscience |
| Zdroj: | Autonomic Neuroscience. 181:55-68 |
| ISSN: | 1566-0702 |
| Popis: | Serotonin is widely distributed throughout the brain and is involved in a multiplicity of visceral, cognitive and behavioral responses. It has been previously shown that injections of different doses of ondansetron, a 5-HT3 receptor antagonist, into the medial septum/vertical limb of the diagonal band complex (MS/vDB) induce a hypertensive response in rats. On the other hand, administration of m-CPBG, a 5-HT3 agonist, into the MS/vDB inhibits the increase of blood pressure during restraint stress. However, it is unclear which neuronal circuitry is involved in these responses. The present study investigated Fos immunoreactive nuclei (Fos-IR) in different brain areas following the blockade of 5-HT3 receptors located in the MS/vDB in sham and in sinoaortic denervated (SAD) rats. Ondansetron injection into the MS/vDB increases Fos-IR in different brain areas including the limbic system (central amygdala and ventral part of the bed nucleus of the stria terminalis), hypothalamus (medial parvocellular parts of the paraventricular nucleus, anterodorsal preoptic area, dorsomedial hypothalamic nucleus), mesencephalon (ventrolateral periaqueductal gray region) and rhombencephalon (lateral parabrachial nucleus) in sham rats. Barodenervation results in higher Fos expression at the parvocellular and magnocellular part of the paraventricular nucleus, the lateral parabrachial nucleus, the central nucleus of amygdala, the locus coeruleus, the medial part of the nucleus of the solitary tract, the rostral ventrolateral medulla and the caudal ventrolateral medulla following 5-HT3receptor blockade in the MS/vDB. Based on the present results and previous data showing a hypertensive response to ondansetron injected into the MS/vDB, it is reasonable to suggest that 5-HT3receptors in the MS/vDB exert an inhibitory drive that may oscillate as a functional regulatory part of the complex central neuronal network participating in the control of blood pressure. |
| Databáze: | OpenAIRE |
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