Eugenol and its association with levodopa in 6-hydroxydopamine-induced hemiparkinsonian rats: Behavioural and neurochemical alterations
| Autor: | Francisco Eduardo Aragão Catunda Junior, Nívea Maria da Cunha Ferreira, Nayanne Hardy Lima Pontes, Rodrigo Maranguape Silva da Cunha, Carlos Franciney Moreira Vasconcelos, Ricardo Basto Souza, Thomas Dominik de Sousa Dos Reis, Lissiana Magna Vasconcelos Aguiar |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Levodopa Parkinson's disease Pharmacology Motor Activity Toxicology medicine.disease_cause 030226 pharmacology & pharmacy Neuroprotection 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Neurochemical Eugenol Medicine Animals Rats Wistar Oxidopamine Nitrites Hydroxydopamine Behavior Animal business.industry Dopaminergic Body Weight Brain Parkinson Disease General Medicine medicine.disease Glutathione nervous system diseases Rats Disease Models Animal Oxidative Stress Neuroprotective Agents chemistry Lipid Peroxidation business 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | Basicclinical pharmacologytoxicologyREFERENCES. 127(4) |
| ISSN: | 1742-7843 |
| Popis: | Parkinson's disease is a neurodegenerative disorder that affects the central nervous system and is mainly characterized by the loss of dopaminergic neurons and pro-oxidant mechanisms. Eugenol has been widely studied due to its anti-inflammatory and antioxidant activities, making it a promising neuroprotective agent. This study aimed to investigate the effects of eugenol and its combined action with levodopa in the 6-hydroxydopamine-induced Parkinson's disease model. Wistar rats were subjected to intrastriatal injection of 6-hydroxydopamine (21 μg) and then treated with eugenol (0.1, 1, or 10 mg/kg), levodopa (25 mg/kg) or their combination (eugenol 10 mg/kg + levodopa 12.5 mg/kg) orally for 14 days. On the 14th day, the animals were subjected to behavioural tests, and after euthanization and dissection of the brain areas, neurochemical analyses were performed. The results showed that eugenol reduced the oxidative stress and behavioural disturbances induced by 6-hydroxydopamine. The eugenol and levodopa combination was more effective in some behavioural parameters and body-weight gain in addition to promoting an increase in reduced glutathione levels compared to levodopa alone. Thus, the neuroprotective activity of eugenol was observed against motor and neurochemical disorders. Additionally, the eugenol and levodopa combination was promising when compared to conventional treatment. |
| Databáze: | OpenAIRE |
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