Differential activation of the renin-angiotensin-aldosterone-system in response to childhood and adulthood trauma
| Autor: | Henry Völzke, Martin Bahls, Anke Hannemann, Sandra Van der Auwera, Deborah Janowitz, Hans J. Grabe, Jan Terock |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
physiopathology [Stress Disorders
Post-Traumatic] Oncology Male Population sample Endocrinology Diabetes and Metabolism Blood Pressure Disease Renin-Angiotensin System Stress Disorders Post-Traumatic chemistry.chemical_compound 0302 clinical medicine Endocrinology Adverse Childhood Experiences Germany Renin Aldosterone metabolism [Stress Disorders Post-Traumatic] Age Factors blood [Aldosterone] physiology [Renin-Angiotensin System] Middle Aged Psychiatry and Mental health Plasma concentration Female Adult medicine.medical_specialty Angiotensins blood [Renin] 03 medical and health sciences Childhood neglect Internal medicine Renin–angiotensin system medicine Humans ddc:610 metabolism [Wounds and Injuries] Biological Psychiatry Aged Endocrine and Autonomic Systems business.industry CTQ tree 030227 psychiatry chemistry physiopathology [Wounds and Injuries] Wounds and Injuries business Increased aldosterone 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | Psychoneuroendocrinology 107, 232-240 (2019). doi:10.1016/j.psyneuen.2019.05.026 |
| ISSN: | 1873-3360 |
| Popis: | Previous evidence suggested lasting and cumulative effects of traumatization on the renin-angiotensin-aldosterone-system (RAAS). However, it is unclear whether traumas during childhood and those experienced in adulthood differentially impact the RAAS. In this study, we sought to investigate main and putative interactive effects of childhood and adulthood trauma on RAAS functioning.Plasma concentrations of renin and aldosterone were measured in a general population sample (n = 2016). Childhood trauma was assessed using the Childhood Trauma Questionnaire (CTQ), adulthood trauma was measured using the PTSD module of the Structured Clinical Interview of the DSM-IV. Linear regression models were calculated to assess the relations between childhood or adulthood traumatization with renin and aldosterone concentrations.Exposure to (ß = 0.094; p = 0.01), severity of childhood trauma (ß = 0.004; p = 0.01) were associated with increased aldosterone, but not renin levels. Results were carried by all dimensions of abuse, while childhood neglect was not associated with altered RAAS activity. In contrast, adulthood traumas (ß = 0.113; p 0.01) were significantly associated with increased renin concentrations. Subjects with PTSD (renin: ß = 0.345; p = 0.01; aldosterone: ß = 0.232; p = 0.04) and those who had been exposed to both childhood and adulthood trauma showed increases in renin (ß = 0.180; p 0.01) and aldosterone (ß = 0.340; p 0.01) levels.These findings indicate that trauma is associated with differential alterations of the RAAS depending on the time of traumatization. Moreover, exposure to childhood or adulthood trauma may act synergistically on the RAAS, resulting in severe dysregulation of the RAAS. The results contribute to explain associations between trauma and enhanced risk for physical disease. |
| Databáze: | OpenAIRE |
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