Timosaponin B-II ameliorates scopolamine-induced cognition deficits by attenuating acetylcholinesterase activity and brain oxidative damage in mice
| Autor: | Ying Jia, Lina Fang, Jie Luo, Chunmei Liu, Kaishun Bi, Xu Zhao, Yu Qi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Scopolamine Morris water navigation task Pharmacology medicine.disease_cause Biochemistry Plant Roots Superoxide dismutase 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound Anemarrhena asphodeloides Mice 0302 clinical medicine Medicine Animals Maze Learning chemistry.chemical_classification Anemarrhena biology business.industry Plant Extracts Glutathione peroxidase Brain Spontaneous alternation Saponins Malondialdehyde biology.organism_classification Acetylcholinesterase Oxidative Stress 030104 developmental biology chemistry biology.protein Steroids Neurology (clinical) Cholinesterase Inhibitors business Cognition Disorders Neuroscience 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Metabolic brain disease. 31(6) |
| ISSN: | 1573-7365 |
| Popis: | Timosaponin B-II (TB-II) is a main active saponin isolated from the rhizome of Anemarrhena asphodeloides Bge., which is widely used in traditional Chinese medicine. In this study, the effect of TB-II on learning and memory was investigated in a scopolamine-induced mouse model of Alzheimer's disease. The results of behavioral tests indicated that TB-II significantly increased the spontaneous alternation in the Y-maze test, and reversed the shortening of step-through latency induced by scopolamine in the passive avoidance test, showing protective effects on short-term and working memory. In the Morris water maze test, TB-II reduced the escape latency time in the training trial, and increased the swimming time in the target quadrant in the probe trial. Biochemical data demonstrated that TB-II significantly inhibited acetylcholinesterase (AChE) activity in the cerebral cortex and hippocampus of mice. Moreover, TB-II markably attenuated the reduction in glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities, and decreased malondialdehyde (MDA) levels, which are key biomarkers of brain oxidative stress. These results indicated that TB-II offers protection against scopolamine-induced deficits in learning and memory, possibly by inhibiting AChE and preventing oxidative stress damage. The findings suggested that TB-II has a potential therapeutic effect on cognitive and behavioral impairment. |
| Databáze: | OpenAIRE |
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