Hostile Takeover: How Viruses Reprogram Prokaryotic Metabolism

Autor:	Melanie M. Callaghan, Daniel Amador-Noguez, Tyler B. Jacobson
Rok vydání:	2021
Předmět:	Primary metabolism viruses Systems biology Metabolism Computational biology Archaeal Viruses Biology Virus Physiological Phenomena Microbiology Prokaryotic Cells Lytic cycle Viruses Protein biosynthesis Reprogramming
Zdroj:	Annual Review of Microbiology. 75:515-539
ISSN:	1545-3251 0066-4227
DOI:	10.1146/annurev-micro-060621-043448
Popis:	To reproduce, prokaryotic viruses must hijack the cellular machinery of their hosts and redirect it toward the production of viral particles. While takeover of the host replication and protein synthesis apparatus has long been considered an essential feature of infection, recent studies indicate that extensive reprogramming of host primary metabolism is a widespread phenomenon among prokaryotic viruses that is required to fulfill the biosynthetic needs of virion production. In this review we provide an overview of the most significant recent findings regarding virus-induced reprogramming of prokaryotic metabolism and suggest how quantitative systems biology approaches may be used to provide a holistic understanding of metabolic remodeling during lytic viral infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f522079ba98fd073614b52bead4e14 https://doi.org/10.1146/annurev-micro-060621-043448 Zobrazit plný text záznamu