British rubber and cable industry cohort: 49-year mortality follow-up
| Autor: | Mira Hidajat, Damien McElvenny, Raymond M Agius, William Mueller, Frank de Vocht, Andrew Darnton, Peter Ritchie, John W. Cherrie |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty industrial cohort study Population 03 medical and health sciences 0302 clinical medicine Neoplasms Occupational Exposure Internal medicine hemic and lymphatic diseases Manufacturing Industry medicine Humans cancer Prospective Studies 030212 general & internal medicine education Prospective cohort study Multiple myeloma Aged rubber and cable industry education.field_of_study Wales Bladder cancer respiratory diseases business.industry Stomach Public Health Environmental and Occupational Health Cancer Middle Aged circulatory diseases medicine.disease mortality 030210 environmental & occupational health Lymphoma Occupational Diseases medicine.anatomical_structure England Cohort Rubber business Follow-Up Studies |
| Zdroj: | Mcelvenny, D M, Mueller, W, Ritchie, P, Cherrie, J W, Hidajat, M, Darnton, A J, Agius, R M & De Vocht, F 2018, ' British rubber and cable industry cohort: 49-year mortality follow-up ', Occupational and Environmental Medicine, vol. 75, no. 12, pp. 848-855 . https://doi.org/10.1136/oemed-2017-104834 McElvenny, D, Mueller, W, Ritchie, P, Cherrie, J, Hidajat, M, Darnton, A, Agius, R & De Vocht, F 2018, ' British rubber and cable industry cohort : 49-year mortality follow-up ', Occupational and Environmental Medicine, vol. 75, no. 12, pp. 848-855 . https://doi.org/10.1136/oemed-2017-104834 |
| DOI: | 10.1136/oemed-2017-104834 |
| Popis: | BackgroundThe International Agency for Research on Cancer (IARC) has determined there is sufficient evidence that working in the rubber manufacturing industry increases the risk of cancers of the stomach, lung, bladder and leukaemia and lymphoma.ObjectivesTo examine mortality patterns of a prospective cohort of men from the rubber and cable manufacturing industries in Great Britain.MethodsSMRs were calculated for males aged 35+ years at start of follow-up in 1967–2015 using the population of England and Wales as the external comparator. Tests for homogeneity and trends in SMRs were also completed.ResultsFor all causes, all malignant neoplasms, non-malignant respiratory diseases and circulatory diseases, SMRs were significantly elevated, and also particularly for cancers of the stomach (SMR=1.26,95% CI 1.18 to 1.36), lung (1.25,95% CI 1.21 to 1.29) and bladder (1.16,95% CI 1.05 to 1.28). However, the observed deaths for leukaemia, non-Hodgkin’s lymphoma (NHL) and multiple myeloma were as expected. Bladder cancer risks were elevated only in workers exposed to antioxidants containing 1-naphthylamine and 2-naphthylamine.ConclusionsThis study provides evidence of excess risks in the rubber industry for some non-cancer diseases and supports IARC’s conclusions in relation to risks for cancers of the bladder, lung and stomach, but not for leukaemia, NHL or multiple myeloma. |
| Databáze: | OpenAIRE |
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