Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila
| Autor: | Qi Zhou, Christopher E. Ellison, Artyom A. Alekseyenko, Nick Toda, Shouyong Peng, Doris Bachtrog, Zaak Walton, Peter J. Park, Andrey A. Gorchakov, Mitzi I. Kuroda, Vera B. Kaiser |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
endocrine system Karyotype Molecular Sequence Data Evolution Molecular Research Communication Dosage Compensation Genetic Genetics Melanogaster Animals Drosophila Proteins Gene Dosage compensation Sex Chromosomes biology fungi Chromosome biology.organism_classification Chromatin Drosophila melanogaster Evolutionary biology Female Drosophila Protein Developmental Biology |
| Popis: | Dosage compensation has arisen in response to the evolution of distinct male (XY) and female (XX) karyotypes. In Drosophila melanogaster, the MSL complex increases male X transcription approximately twofold. X-specific targeting is thought to occur through sequence-dependent binding to chromatin entry sites (CESs), followed by spreading in cis to active genes. We tested this model by asking how newly evolving sex chromosome arms in Drosophila miranda acquired dosage compensation. We found evidence for the creation of new CESs, with the analogous sequence and spacing as in D. melanogaster, providing strong support for the spreading model in the establishment of dosage compensation. |
| Databáze: | OpenAIRE |
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