Acute heat stress model of seizures in weanling rats: Influence of prototypic anti-seizure compounds
Autor: | Alfonso R. Borrelli, Thomas J. Hudzik, Sheldon B. Sparber, Gene C. Palmer |
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Rok vydání: | 1998 |
Předmět: |
Hot Temperature
medicine.medical_treatment Weanling Weaning Neurological disorder Body Temperature Rats Sprague-Dawley chemistry.chemical_compound Epilepsy Seizures Stress Physiological medicine Animals Remacemide Valproic Acid business.industry medicine.disease Clonazepam Rats Anticonvulsant Animals Newborn Neurology chemistry Anesthesia Acute Disease Anticonvulsants Phenobarbital Neurology (clinical) business medicine.drug |
Zdroj: | Epilepsy Research. 30:203-217 |
ISSN: | 0920-1211 |
Popis: | The present study tested the therapeutic potential for prototype anti-epilepsy drugs using an animal model of infantile febrile seizures. The model consisted of immersion of weanling rats (21 days old) in a 45°C water bath for a maximum of 4 min (four exposures over a 2 week period) and observing for the progression to stage-5 seizures. All compounds were administered orally at the respective ED 50 for prevention of seizures in the maximal electroshock (MES) test. Clonazepam effectively lowered the score for seizure grade, shortened the duration of seizures, as well as reduced the number of animals experiencing seizures during three of the four testing periods. MK801 reduced both the maximum seizure grade, and the number of animals experiencing seizures during sessions two and three. However, the dose of MK801 caused behavioral side effects. Valproate actively decreased seizure grade, while it modestly acted to attenuate seizure duration, extended the time to seizure onset, and reduced the number of animals experiencing seizures on testing day 1. Remacemide hydrochloride and phenobarbital were not effective. The method appears useful for evaluating the potential of agents to prevent acute febrile seizures. |
Databáze: | OpenAIRE |
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