Renal transplant biopsy specimen adequacy in a paediatric population
| Autor: | John H. McColl, Anne M. Durkan, Ian J. Ramage, Allan G. Howatson, T. James Beattie |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Nephrology
medicine.medical_specialty Adolescent medicine.diagnostic_test business.industry Sedation Biopsy Needle Gold standard (test) medicine.disease Kidney Transplantation Surgery Specimen collection Child Preschool Internal medicine Pediatrics Perinatology and Child Health Biopsy medicine Humans Sampling (medicine) Renal biopsy medicine.symptom Child business Kidney transplantation |
| Zdroj: | Pediatric Nephrology. 21:265-269 |
| ISSN: | 1432-198X 0931-041X |
| Popis: | Updated guidelines on the diagnosis of acute allograft rejection including criteria for biopsy specimen adequacy were published in 1999. We sought to determine the adequacy of specimens in paediatric transplant patients and identify factors influencing adequacy. All renal transplant biopsies performed between 1998 and 2003 were classified as adequate (n =25), minimal (n =19) or inadequate (n =27) in accordance with the Banff 97 criteria, and the histological diagnoses were documented. The effect on specimen adequacy of grade of operator, method of sedation, age of child, needle gauge, number of cores and total core length was then investigated. Overall, a minimal or adequate specimen was obtained in 62% of cases. No histological diagnosis could be made in 30% of all specimens, just over half of which were inadequate. Higher rates of rejection were found in adequate (52%) than inadequate (33%) samples. The grade of operator (p =0.498), the age of the child at the time of biopsy (p =0.815) and type of sedation (p =0.188) did not affect adequacy. More than one core was obtained in 38 (54%) cases, and this was significantly associated with specimen adequacy (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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